Easy and fun to play. Use delay, and slight distortion. e|-----4-9-4-5-2-0-2------------4-9-2-5-4-2---4---| b|-2-----------------4----0-2---------------------| d|------------------------------------------------| g|------------------------------------------------| a|------------------------------------------------| e|------------------------------------------------| You should be able to get the timing and know which notes to let ring. Just load up the game real quick if you have to. There's another noise in it, though. This probably isn't right... Slight distortion again, and you'll need a whammy bar. e|------------------------------------------------| b|------------------------------------------------| d|------------------------------------------------| g|------------------------------------------------| a|---3v----5^-------------------------------------| e|------------------------------------------------| v = Gently move the whammy bar down. ^ = Gently move the whammy bar up. It sort of sounds like it, but just fiddle around with it. You can't play the two of them at the same time (and have them sound good), anyway. I've been trying to find a way to make the box open noise, so I may add that in the future just for fun if I ever get something that sounds reasonable.
https://primanota.net/misc-computer-games/resident-evil-2-save-room-chords.htm